Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells.

@article{Mrak2007GrowthHS,
  title={Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells.},
  author={Emanuela Mrak and Isabella Villa and Roberto Lanzi and Marco Losa and Francesca Guidobono and Alessandro Rubinacci},
  journal={The Journal of endocrinology},
  year={2007},
  volume={192 3},
  pages={639-45}
}
It is presently thought that osteoprotegerin (OPG) is a cytokine involved in the regulation of osteoblast/osteoclast crosstalk and maintenance of bone mass. Recent studies showed that GH replacement therapy in GH-deficient patients was able to induce a significant increase of OPG in the plasma, as well as in the cortical and the trabecular bone. In order to determine whether GH could directly modulate OPG secretion, the effect of GH on human osteoblast-like cells (hOB) in primary culture was… CONTINUE READING
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