Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex.

@article{Xu2011GrowthHS,
  title={Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex.},
  author={Jie Xu and Yue Zhang and Philip A. Berry and Jing Jiang and Peter E. Lobie and John Fairbanks Langenheim and Wen Yuan Chen and Stuart J. Frank},
  journal={Molecular endocrinology},
  year={2011},
  volume={25 4},
  pages={597-610}
}
GH receptor (GHR) and prolactin (PRL) receptor (PRLR) are structurally similar cytokine receptor superfamily members that are highly conserved among species. GH has growth-promoting and metabolic effects in various tissues in vertebrates, including humans. PRL is essential for regulation of lactation in mammals. Recent studies indicate that breast tissue… CONTINUE READING