Growth hormone signal transduction.

  title={Growth hormone signal transduction.},
  author={Graciela Piwien-Pilipuk and Jeffrey S. Huo and Jessica E Schwartz},
  journal={Journal of pediatric endocrinology & metabolism : JPEM},
  volume={15 6},
Multiple signaling pathways mediate the diverse effects of growth hormone (GH) on growth and metabolism. The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. GH-stimulated activation of signal transducers and activators of transcription (STATs), mitogen activated protein kinase (MAPK) and phosphatidylinositol 3… CONTINUE READING


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Growth hormone signaling pathways.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society • 2016
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