Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls.

@article{Siever1982GrowthHR,
  title={Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls.},
  author={Larry J. Siever and Thomas W. Uhde and Edward K Silberman and David C. Jimerson and J A Aloi and Robert M Post and Dennis L. Murphy},
  journal={Psychiatry research},
  year={1982},
  volume={6 2},
  pages={171-83}
}
The growth hormone (GH) response to the alpha-adrenergic agonist clinidine was blunted in 19 depressed patients compared to 20 controls. The difference remained significant when age- and sex-matches pairs of patients and controls were compared from this sample, either including or excluding subjects with elevated GH baseline levels. Plasma levels of free 3-methoxy-4-hydroxyphenyl-glycol (MHPG) were assayed in blood samples drawn just before the clonidine infusion. A modest negative correlation… CONTINUE READING