Growth hormone-releasing peptides and their analogs.

  title={Growth hormone-releasing peptides and their analogs.},
  author={Franco Camanni and Ezio Ghigo and Emanuela Arvat},
  journal={Frontiers in neuroendocrinology},
  volume={19 1},
Growth hormone-releasing peptides (GHRPs) are a series of hepta (GHRP-1)- and hexapeptides (GHRP-2, GHRP-6, Hexarelin) that have been shown to be effective releasers of GH in animals and humans. More recently, a series of nonpeptidyl GH secretagogues (L-692,429, L-692,585, MK-0677) were discovered using GHRP-6 as a template. Some cyclic peptides as well as penta-, tetra-, and pseudotripeptides have also been described. This review summarizes recent developments in our understanding of the GHRPs… CONTINUE READING


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