Growth hormone-releasing hormone expression in pituitary somatotroph adenomas, studied by immunohistochemistry and in situ hybridization using catalyzed signal amplification system.

@article{Matsuno2000GrowthHH,
  title={Growth hormone-releasing hormone expression in pituitary somatotroph adenomas, studied by immunohistochemistry and in situ hybridization using catalyzed signal amplification system.},
  author={Akira Matsuno and Hideki Katakami and Tadashi Nagashima and Akira Teramoto and Robert Yoshiyuki Osamura and Takaaki Kirino},
  journal={Human pathology},
  year={2000},
  volume={31 7},
  pages={789-94}
}
Growth hormone-releasing hormone (GHRH) is a well-known hypothalamic hormone that stimulates the synthesis and release of growth hormone (GH) as well as the proliferation of GH-producing cells in the anterior pituitary gland. Recent reports have shown GHRH synthesis in pituitary somatotroph adenomas, but GHRH immunoreactivity has not been shown in previous studies. To confirm the role of locally generated GHRH for the progression of somatotroph adenomas, we investigated the expression of GHRH… CONTINUE READING