Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice

@inproceedings{Sun2013GrowthHH,
  title={Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice},
  author={Liou Y Sun and Adam Spong and William R Swindell and Yimin Fang and Cristal Monique Hill and Joshua A Huber and Jacob D Boehm and R. Niccole Westbrook and Roberto Salvatori and Andrzej Bartke},
  booktitle={eLife},
  year={2013}
}
We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress resistance, and insulin signaling. These mutant mice also have increased adiponectin levels and alterations in glucose homeostasis consistent with the removal of the counter-insulin effects of growth… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Similar Papers

Loading similar papers…