Growth hormone-releasing hormone: not only a neurohormone

  title={Growth hormone-releasing hormone: not only a neurohormone},
  author={Hippokratis Kiaris and Ioulia Chatzistamou and Athanasios G. Papavassiliou and Andrew V. Schally},
  journal={Trends in Endocrinology \& Metabolism},

A Glimpse at Growth Hormone Releasing Hormone Cosmos.

  • N. Barabutis
  • Biology, Medicine
    Clinical and experimental pharmacology & physiology
  • 2020
The present effort provides information regarding the effects of growth hormone releasing hormone in the regulation of P53 and the unfolded protein response and suggests the possible application of growth hormones releasing hormone antagonists towards the management of acute lung injury, including the lethal acute respiratory distress syndrome.

Growth Hormone-Releasing Hormone in Lung Physiology and Pulmonary Disease

The novel data reviewed here show that G HRH is an important peptide that participates in lung homeostasis, inflammation, wound healing, and cancer; and GHRH-R antagonists may have therapeutic potential in lung diseases.

Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice

It is found that endogenous ACh levels determined the concentrations of circulating GH and IGF-1 at embryonic and postnatal stages, and serum GH level was correlated with brain ACh content, which identifies ACh as a potential regulator of the somatotropic axis during the developmental period.

Growth hormone releasing hormone in the unfolded protein response context

The possible involvement of Growth Hormone Releasing Hormones and its agonistic and antagonistic analogs in those events, may deliver exciting possibilities in the treatment of human disease, including the Acute Respiratory Distress Syndrome.

Potentiation of cytotoxic chemotherapy by growth hormone-releasing hormone agonists

The findings indicate that the GHRH agonists can potentiate the anticancer activity of the traditional chemotherapeutic drug, DOX, by multiple mechanisms including the induction of differentiation of cancer cells.

Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone‐releasing hormone

The development of GHRH antagonists (GHRHAnt) delivers an exciting possibility to counteract the pathogenesis of the G HRH‐related effects in human pathophysiology, especially when considered that G HRHAnt support endothelial barrier integrity.

Differential modulation of ghrelin-induced GH and LH release by PACAP and dopamine in goldfish pituitary cells.




Growth hormone-releasing hormone: Extrapituitary effects in physiology and pathology

GHRH and its agonists have been shown to contribute to the recovery of heart tissue after myocardial infarction and can promote the survival and proliferation of pancreatic islets after transplantation into diabetic animals.

Neuroendocrine control of growth hormone secretion.

The secretion of growth hormone (GH) is regulated through a complex neuroendocrine control system, especially by the functional interplay of two hypothalamic hypophysiotropic hormones, GH-releasing

A novel peptide from the growth hormone releasing hormone gene stimulates Sertoli cell activity.

It is discovered that the GHRH mRNA encodes a second peptide that is abundant in testicular germ cells and specifically activates Sertoli cell expression of stem cell factor, a factor crucial for the normal progression of spermatogenesis.

Growth hormone releasing hormone receptor.

  • B. Gaylinn
  • Biology, Medicine
    Receptors & channels
  • 2002
Topics touched on in this article are the receptor gene's organization and promoter regulation, receptor signaling pathways, and receptor domains involved in interaction with ligand, and alternative mRNA splicing.

Endocrine and antineoplastic actions of growth hormone-releasing hormone antagonists.

This work has demonstrated the expression of hGHRH-R and its splice variants in various human cancers and indicates that GHRH functions as an autocrine growth factor and that G HRH antagonists can block its effects on tumor growth.

Ghrelin and anterior pituitary function.

Ghrelin and synthetic GHS possess an acute stimulatory effect on the activity of the hypothalamus-pituitary-adrenal axis in humans, which is, at least, similar to that of the opioid antagonist naloxone, arginine vasopressin and even corticotropin-releasing hormone.

Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates

Evidence is provided for a previously uncharacterized G HRH-GHRH-R axis in nonmammalian vertebrates and a comprehensive evolutionary scheme for GHRH, PRP-PACAP, and PHI-VIP genes in relation to three rounds of genome duplication early on in vertebrate evolution is proposed.

Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour

A synthetic replicate of this peptide, termed human pancreatic tumour GRF [hpGRF(1–40)]-OH, co-elutes on HPLC with the native peptide and is highly potent in stimulating GH secretion in vitro and in vivo.

Functional maturation of growth hormone cells in the anterior pituitary gland of the fetus.

  • H. NogamiS. Hisano
  • Biology, Medicine
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2008