Growth hormone-releasing factor increases somatostatin release and mRNA levels in the rat periventricular nucleus via nitric oxide by activation of guanylate cyclase.

@article{Aguila1994GrowthHF,
  title={Growth hormone-releasing factor increases somatostatin release and mRNA levels in the rat periventricular nucleus via nitric oxide by activation of guanylate cyclase.},
  author={M C Aguila},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 2},
  pages={782-6}
}
  • M C Aguila
  • Published 1994 in
    Proceedings of the National Academy of Sciences…
Previous work has shown that growth hormone-releasing factor (GRF) stimulates cGMP production and somatostatin [somatotropin (growth hormone)-release-inhibiting factor, SRIF] release without altering cAMP accumulation by fragments of median eminence incubated in vitro. Therefore, this study was undertaken to evaluate the effect of GRF and cGMP on SRIF mRNA and SRIF release in the periventricular nuclei of male rats in vitro. SRIF mRNA levels were determined in explants of periventricular nuclei… CONTINUE READING
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