Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man.

@article{Ghigo1994GrowthHA,
  title={Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man.},
  author={E. Ghigo and E. Arvat and L. Gianotti and B. Imbimbo and V. Lenaerts and R. Deghenghi and F. Camanni},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1994},
  volume={78 3},
  pages={
          693-8
        }
}
We evaluated the GH-releasing activity of hexarelin, a new synthetic hexapeptide, after i.v. (1 and 2 micrograms/kg), sc (1.5 and 3 micrograms/kg), intranasal (20 micrograms/kg), and oral (po; 20 and 40 mg) administration to 12 healthy young volunteers. Reference treatments were i.v. saline and GH-releasing hormone (GHRH; 1 microgram/kg). GH release (mean +/- SEM) after the i.v. dose of 1 microgram/kg hexarelin [area under the curve (AUC), 3175 +/- 506 micrograms/min.L] was about 2 times higher… Expand
Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, before and during puberty.
Kinetics and disposition of hexarelin, a peptidic growth hormone secretagogue, in rats.
The GH-Releasing Effect of Hexarelin, a Synthetic Hexapeptide, in Newborns is Lower than in Young Adults
Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study.
Tyr-Ala-Hexarelin, a synthetic octapeptide, possesses the same endocrine activities of hexarelin and GHRP-2 in humans
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 15 REFERENCES
GH Releasing Peptides - Structure and Kinetics
  • C. Bowers
  • Medicine
  • The Journal of pediatric endocrinology
  • 1993
...
1
2
...