Growth hormone receptor: structure function relationships.

  title={Growth hormone receptor: structure function relationships.},
  author={Michael J. Waters and Andrew J. Brooks},
  journal={Hormone research in paediatrics},
  volume={76 Suppl 1},
BACKGROUND The growth hormone receptor (GHR) was the first class 1 cytokine receptor to be cloned, and it has been studied intensively. The crystal structures of the bound and unbound forms have been solved and the energetic contributions of residues involved in the binding interaction have been quantified. Two receptor subunits bind to opposite sides of the hormone through site 1 and site 2, and a third interaction occurs between receptors in the lower β-sandwich module at site 3. All three… CONTINUE READING

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