Growth hormone prevents steroid-induced growth depression in health and uremia

  title={Growth hormone prevents steroid-induced growth depression in health and uremia},
  author={Gabor Kovacs and R. H. Fine and Stefan Worgall and Franz Schaefer and Ernst Bruno Hunziker and A. Skottner-Lindun and Otto Mehls},
  journal={Pediatric Nephrology},
Treatment with supraphysiological doses of corticosteroids results in protein wasting and impairment of growth, whereas exogenous growth hormone (GH) causes anabolism and improvement of growth. We wanted to know whether the growth depressing effects of methylprednisolone (MP) are more expressed in an organism which is chronically diseased and whether these effects can be counterbalanced by concomitant treatment with recombinant human growth hormone (rhGH). MP in doses from 1 to 9 mg/kg/day… CONTINUE READING


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