Growth hormone peak modifies the effect of BMI on increased systolic blood pressure in children with short stature

  title={Growth hormone peak modifies the effect of BMI on increased systolic blood pressure in children with short stature},
  author={Yanying Li and Yanhong Zhang and Mei Zhang and Wanling Yang and Baolan Ji and H. Pan and B. Ban},
  journal={Scientific Reports},
Blood pressure (BP), especially systolic BP (SBP), is higher in adult growth hormone deficiency (AGHD) patients than in normal controls. Additionally, obesity is a known risk factor for hypertension, and growth hormone deficiency (GHD) is an important cause of short stature. For children with GHD, attention has been directed solely towards height. Few studies have assessed its potential impact on BP. Here, we investigated the effect of body mass index standard deviation score (BMISDS) on BP in… Expand
4 Citations
Association between systolic blood pressure and uric acid in Chinese children and adolescents with idiopathic short stature: a cross-sectional study
This study found a nonlinear relationship between UA and SBP in Chinese children and adolescents with ISS and showed that SBP levels were associated positively with the rise of UA levels when the UA levels reached the inflection point. Expand
Effects of ammonia on growth performance, lipid metabolism and cecal microbial community of rabbits
In conclusion, ammonia treatment was responsible for an imbalance of intestinal flora, which affected lipid metabolism and damaged intestinal barrier of rabbits, resulting in low growth performance due to lipid metabolism dysfunction. Expand
Faecal microbiota and functional capacity associated with weaning weight in meat rabbits
It was found that gut microbiota involved in the metabolism of amino acids, butanoate, energy and monosaccharides affected weaning weight and cross‐validation analysis indicated that 16.16% of the variation in weaningWeight was explained by the gut microbiome. Expand
Growth Hormone Deficiency: Is It Just a Problem of Growth Impairment? Part I
The concept that the growth hormone (GH) is a merely metabolic pituitary hormone with effects on the longitudinal growth of the organism until the end of puberty has been questioned in recent years.Expand


Familial isolated growth hormone deficiency is associated with increased systolic blood pressure, central obesity, and dyslipidemia.
This genetically homogeneous isolated GHD population presents a syndrome characterized by central obesity, dyslipidemia, and elevated SBP but reduced cardiac dimensions compared with controls. Expand
Severe growth hormone deficiency and empty sella in obesity: a cross-sectional study
Pituitary morphology in obese patients with suspected GHD and its association with cardiovascular risk factors, body composition, and cardiac morphology is explored and empty sella (ES) was a significant independent predictor of GH secretory capacity as determined by multiple regression analysis. Expand
Metabolic differences between short children with GH peak levels in the lower normal range and healthy children of normal height.
The short pre-pubertal short children with GH peak levels between 7 and 14μg/L did not differ significantly from healthy children of normal height but subpopulations within this group show significant metabolic differences. Expand
Muscle function improves during growth hormone therapy in short children born small for gestational age: results of a peripheral quantitative computed tomography study on body composition.
Supraphysiological GH doses led to a concomitant increment in height, muscle mass, and function, whereas fat mass decreased, and body composition at GH start gives insight into GH responsiveness and the individual risk of metabolic syndrome. Expand
Metabolic alterations in paediatric GH deficiency.
Growth hormone (GH) has a large number of metabolic effects, involving lipid and glucose homoeostasis, lean and fat mass. Growth hormone deficiency (GHD) is associated with a metabolic profileExpand
Effects of Growth Hormone Replacement on Peripheral Muscle and Exercise Capacity in Severe Growth Hormone Deficiency
Short-term rGH for 3 months normalized IGF1 levels, reduced fat mass, and had a significant effect on mitochondrial function, but exercise capacity was unchanged. Expand
Cardiovascular risk in adult patients with growth hormone (GH) deficiency and following substitution with GH--an update.
The GHD population may be considered at high cardiovascular risk, and GH substitution may be expected to bring an added value to patients with hypopituitarism in terms of cardiovascular protection, but there is too limited evidence to recommend GH treatment based on the cardiovascular status of the patients. Expand
Lipid Accumulation Product: a Simple and Accurate Index for Predicting Metabolic Syndrome in Patients with Adult Growth Hormone Deficiency.
  • L. Chan, H. Xue, +5 authors L. Lan
  • Medicine
  • Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 2016
LAP was associated with MS and had a strong and reliable diagnostic accuracy for MS in AGHD patients and LAP was highly correlated with components of MS. Expand
Growth Hormone Deficiency in Prepubertal Children: Predictive Markers of Cardiovascular Disease
The aim of this review is to point out the most significant biochemical and clinical predictive markers of CV disease in prepubertal children and to evaluate the effect of recombinant human growth hormone therapy on most of these alterations. Expand
Association between Insulin-Like Growth Factor-1 and Uric Acid in Chinese Children and Adolescents with Idiopathic Short Stature: A Cross-Sectional Study
A nonlinear relationship between IGF-1 and UA levels in Chinese children and adolescents with ISS suggests that either high or low levels of UA may have an adverse effect on IGF- 1, whereas appropriate UA levels have a beneficial effect. Expand