Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.

@article{BohloolyY2005GrowthHO,
  title={Growth hormone overexpression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and dyslipidemia.},
  author={Mohammad Bohlooly-Y and Bob Olsson and Carl E. G. Bruder and Daniel Lind{\'e}n and Klara Sj{\"o}gren and Mikael Bjursell and Emil Egecioglu and Lennart Svensson and Peter Brodin and John C. Waterton and Olle G. P. Isaksson and Frank Sundler and Bo Ahr{\'e}n and C Ohlsson and Jan Oscarsson and Jan T{\"o}rnell},
  journal={Diabetes},
  year={2005},
  volume={54 1},
  pages={51-62}
}
It is well known that peripherally administered growth hormone (GH) results in decreased body fat mass. However, GH-deficient patients increase their food intake when substituted with GH, suggesting that GH also has an appetite stimulating effect. Transgenic mice with an overexpression of bovine GH in the central nervous system (CNS) were created to investigate the role of GH in CNS. This study shows that overexpression of GH in the CNS differentiates the effect of GH on body fat mass from that… CONTINUE READING

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