Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.

@article{Molina2012GrowthHM,
  title={Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.},
  author={Doris P. Molina and Olusegun J. Ariwodola and Constance Linville and William Edmund Sonntag and J. L. Weiner and Judy Karen Brunso-Bechtold and M. M. Adams},
  journal={Neurobiology of aging},
  year={2012},
  volume={33 9},
  pages={1938-49}
}
Alterations in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPA-R) and N-methyl-D-aspartate receptor (NMDA-R) have been documented in aged animals and may contribute to changes in hippocampal-dependent memory. Growth hormone (GH) regulates AMPA-R and NMDA-R-dependent excitatory transmission and decreases with age. Chronic GH treatment mitigates age-related cognitive decline. An in vitro CA1 hippocampal slice preparation was used to compare hippocampal excitatory… CONTINUE READING