Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1alpha.

@article{Metn1999GrowthHI,
  title={Growth hormone induces insulin-like growth factor-I gene transcription by a synergistic action of STAT5 and HNF-1alpha.},
  author={Isidoro Met{\'o}n and Elmieke P. J. Boot and John S. Sussenbach and Paul H Steenbergh},
  journal={FEBS letters},
  year={1999},
  volume={444 2-3},
  pages={155-9}
}
Salmon insulin-like growth factor-I (sIGF-I) expression is, as in mammals, induced by growth hormone (GH). To elucidate the mechanism by which GH stimulates the transcription of the IGF-I gene, we transiently transfected Hep3B cells expressing the rat GH receptor with a sIGF-I promoter-luciferase reporter construct. Activation of the construct by GH added to the medium of the transfected cells was observed when two specific transcription factors, STAT5 and HNF-1alpha, were simultaneously… CONTINUE READING

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