Growth hormone increases lung NF-kappaB activation and lung microvascular injury induced by lipopolysaccharide in rats.

@article{Liu2002GrowthHI,
  title={Growth hormone increases lung NF-kappaB activation and lung microvascular injury induced by lipopolysaccharide in rats.},
  author={Zhihai Liu and Yingqun Yu and Yun Jiang and Jie-shou Li},
  journal={Annals of clinical and laboratory science},
  year={2002},
  volume={32 2},
  pages={164-70}
}
The purpose of this study was to examine the effects of growth hormone (GH) on nuclear factor kappa B (NF-kappaB) activation and organ injury induced by lipopolysaccharide (LPS) in rats. Male Wistar rats were divided into 6 groups treated with saline, LPS (5 mg/kg), LPS plus GH (0.5, 1.0, 2.0 mg/kg), or GH (2.0 mg/kg) alone for 2 or 4 hr. NF-kappaB activity and I-kappaB level in lung, lung accumulation of neutrophils, and lung microvascular injury were measured. LPS-challenged rats had… CONTINUE READING