Growth hormone in health and disease: Novel ghrelin mimetic is safe and effective as a GH stimulation test

@article{Koch2013GrowthHI,
  title={Growth hormone in health and disease: Novel ghrelin mimetic is safe and effective as a GH stimulation test},
  author={Linda Koch},
  journal={Nature Reviews Endocrinology},
  year={2013},
  volume={9},
  pages={315-315}
}
  • Linda Koch
  • Published 16 April 2013
  • Medicine, Biology
  • Nature Reviews Endocrinology
Growth hormone in health and disease: Novel ghrelin mimetic is safe and effective as a GH stimulation test 
Ghrelin - Physiological Functions and Regulation.
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This review explains what ghrelin is, its physiological functions and the factors that influence its level, and explains the balance among its secretion rate, degradation rate and clearance rate.
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This review investigates the current understanding of appetite regulation and subsequent dysregulation with age, and the age-associated changes in the anorectic and orexigenic pathways, thereby implicating the POMC and AgRP neurons.

References

Macimorelin (AEZS-130)-Stimulated Growth Hormone (GH) Test: Validation of a Novel Oral Stimulation Test for the Diagnosis of Adult GH Deficiency
TLDR
Oral macimorelin is safe, convenient, and effective in diagnosing AGHD with accuracy comparable with the arginine+GHRH test.