Growth hormone deficiency associated in the 18q deletion syndrome.

  title={Growth hormone deficiency associated in the 18q deletion syndrome.},
  author={Patricia Davis Ghidoni and Daniel Esten Hale and Jannine D. Cody and Carolina Gay and Nora M. Thompson and Erin B. McClure and Mark M. Danney and Robin J. Leach and Celia I. Kaye},
  journal={American journal of medical genetics},
  volume={69 1},
The 18q- syndrome is one of the commonest deletion syndromes. Clinical characteristics are variable but may include: hypotonia, tapered digits, "carp-like" mouth, mental retardation, and hearing impairment. Growth failure (GF; both weight and height < 3%) was reported in 80% of affected individuals. We evaluated growth hormone (GH) sufficiency in 5 18q- syndrome patients, 3 of whom had growth failure (< 3% weight and height); the remaining 2 had normal growth parameters. Laboratory evaluation… CONTINUE READING
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