Growth hormone causes rapid induction of lactogenic receptor activity in the Snell dwarf mouse liver.

@article{Knazek1978GrowthHC,
  title={Growth hormone causes rapid induction of lactogenic receptor activity in the Snell dwarf mouse liver.},
  author={Richard A. Knazek and Songyong Liu and R L Graeter and Patricia C Wright and Jennifer L R Mayer and Rh. Lewis and Elizabeth Gould and Joe Keller},
  journal={Endocrinology},
  year={1978},
  volume={103 5},
  pages={
          1590-6
        }
}
The Snell dwarf mouse (dw/dw) has no detectable PRL-binding sites in the microsomal fractions of its liver. Both bGH and bPRL, purified by preparative gel electrophoresis, induce PRL-binding sites when injected into dw/dw. Intraperitoneal injection of 100 micrograms bGH every 8 h results in the appearance of a high affinity PRL receptor 8--16 h after initiation of treatment. This induced binding capacity plateaus after 32 h of treatment and subsequently decreases to nondetectable levels 48 h… CONTINUE READING
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