Growth hormone-binding protein related immunoreactivity is regulated by the degree of insulinopenia in diabetes mellitus.

@article{Kratzsch1996GrowthHP,
  title={Growth hormone-binding protein related immunoreactivity is regulated by the degree of insulinopenia in diabetes mellitus.},
  author={J{\"u}rgen Kratzsch Kratzsch and K Keliner and T M Zilkens and Heinrich E. Schmidt-Gayk and Thomas Selisko and Gerhard H. Scholz},
  journal={Clinical endocrinology},
  year={1996},
  volume={44 6},
  pages={673-8}
}
OBJECTIVE Derangements in the GH/IGF axis are common in patients with diabetes mellitus. In insulin-dependent diabetes mellitus (IDDM), these disturbances seem to be due to a partial defect in GH action on its own receptor or via a post-receptor defect. In non-insulin-dependent diabetes mellitus (NIDDM), data are limited, and the regulation of the GH receptor (GHR) remains unclear. However, animal studies with diabetic rats demonstrated that the GHR density may be influenced by insulin disposal… CONTINUE READING

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