Growth hormone axis in chronic kidney disease

  title={Growth hormone axis in chronic kidney disease},
  author={Shefali Mahesh and Frederick J. Kaskel},
  journal={Pediatric Nephrology (Berlin, Germany)},
  pages={41 - 48}
Chronic kidney disease (CKD) in children is associated with dramatic changes in the growth hormone (GH) and insulin-like growth factor (IGF-1) axis, resulting in growth retardation. Moderate-to-severe growth retardation in CKD is associated with increased morbidity and mortality. Renal failure is a state of GH resistance and not GH deficiency. Some mechanisms of GH resistance are: reduced density of GH receptors in target organs, impaired GH-activated post-receptor Janus kinase/signal… CONTINUE READING
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