Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells

@article{Kimata1994GrowthHA,
  title={Growth hormone and insulin-like growth factor I induce immunoglobulin (Ig)E and IgG4 production by human B cells},
  author={Hajime Kimata and M Fujimoto},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={727 - 732}
}
We studied the effects of growth hormone (GH), insulin-like growth factor I (IGF-I), IGF-II, and insulin on human immunoglobulin E (IgE) and IgG4 production. GH and IGF-I induced IgE and IgG4 production by normal donors' mononuclear cells (MNC) depleted of sIgE+ and sIgG4+ B cells without affecting IgM, IgG1, IgG2, IgG3, IgA1, or IgA2 production, whereas IGF-II and insulin failed to do so. GH-induced IgE and IgG4 production was specific, and was not mediated by IGF-I, interleukin 4 (IL-4), or… CONTINUE READING
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IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferon 3/and ot and prostaglandin E2

  • J. Prne, F. Rousset, +9 authors andJ.E. de Vries
  • Proc. Natl. Acad. Sci. USA
  • 1988
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