Growth hormone and insulin-like growth factor I protect intestinal cells from radiation induced apoptosis.

@article{Mylonas2000GrowthHA,
  title={Growth hormone and insulin-like growth factor I protect intestinal cells from radiation induced apoptosis.},
  author={Panagiotis G Mylonas and Panagiota Matsouka and Eleni Papandoniou and C Vagianos and Fotis E Kalfarentzos and Theodoros Alexandrides},
  journal={Molecular and cellular endocrinology},
  year={2000},
  volume={160 1-2},
  pages={115-22}
}
We studied whether programmed cell death (or apoptosis) is the predominant mechanism in radiation-induced cell damage to rat intestinal mucosa and investigated the mechanism of the protective effect of GH and IGF-I in the same model. Male albino Wistar rats were divided into four groups: controls, radiation, radiation plus GH and radiation plus IGF-I. Radiation was administered on the first day and on day 4. All animals were sacrificed and segments of the terminal ileum were stained with… CONTINUE READING
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