Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice.

@article{BrownBorg2005GrowthHA,
  title={Growth hormone alters methionine and glutathione metabolism in Ames dwarf mice.},
  author={Holly M Brown-Borg and Sharlene G. Rakoczy and Eric O. Uthus},
  journal={Mechanisms of ageing and development},
  year={2005},
  volume={126 3},
  pages={389-98}
}
Reduced signaling of the growth hormone (GH)/insulin-like growth factor-1(IGF-1)/insulin pathway is associated with extended life span in several species. Ames dwarf mice are GH and IGF-1 deficient and live 50-64% longer than wild type littermates (males and females, respectively). Previously, we have shown that Ames mice exhibit elevated levels of antioxidative enzymes and lower oxidative damage. To further explore the relationship between GH and antioxidant expression, we administered GH or… CONTINUE READING