Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.

@article{Chen2003GrowthHA,
  title={Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice.},
  author={Benny J Chen and Xiuyu Cui and Gregory D. Sempowski and Nelson J. Chao},
  journal={Experimental hematology},
  year={2003},
  volume={31 10},
  pages={
          953-8
        }
}
Growth Hormone Mitigates against Lethal Irradiation and Enhances Hematologic and Immune Recovery in Mice and Nonhuman Primates
TLDR
It is demonstrated that rhGH promotes hematopoietic engraftment and immune recovery post the exposure of ionizing radiation and mitigates against the mortality from lethal irradiation even when administered after exposure.
α-GalCer administration after allogeneic bone marrow transplantation improves immune reconstitution in mice.
Ghrelin Protects the Thymic Epithelium From Conditioning-Regimen-Induced Damage and Promotes the Restoration of CD4+ T Cells in Mice After Bone Marrow Transplantation
TLDR
The findings suggest that GRL may be a novel potential therapeutic approach to protecting the thymic epithelium from conditioning regimen–induced damage and promoting rapid and durableThymic and peripheral CD4+ T cell recovery after HSCT.
Improvement of Thymopoiesis after Hematopoietic Stem Cell Transplantation by Cytokines: Translational studies in experimental animal models
TLDR
New strategies that may improve thymopoiesis are addressed, including the post-transplant administration of cytokines that are physiologically involved in the differentiation and proliferation of thymocytes.
Hematopoietic growth factors including keratinocyte growth factor in allogeneic and autologous stem cell transplantation.
TLDR
Progress has been made towards enhancing immune reconstitution with hematopoietic growth factors (HGFs) such as granulocyte colony-stimulating factor (G-CSF) or erythropoietin (EPO) or through the application of cytokines, and approaches to promote the thymic-dependent development of naive T cells, which are prepared for the interaction with a multitude of pathogens.
Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation: Time To T Up the Thymus
TLDR
The success of allogeneic hematopoietic stem cell transplantation, a key treatment for many disorders, is intertwined with T cell immune reconstitution, and there is a need to develop exogenous strategies to help regenerate the thymus.
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References

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Recombinant Human Growth Hormone Promotes Hematopoietic Reconstitution after Syngeneic Bone Marrow Transplantation in Mice
TLDR
Analysis of peripheral blood indicated that administration of rhGH resulted in significant increases in the rate of white blood cell and platelet recovery, and rhGH administration after syngeneic BMT promoted multilineage hematopoietic reconstitution and may be of clinical use for accelerating hematoiesis after autologous BMT.
Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice.
  • W. Murphy, S. Durum, D. Longo
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
TLDR
Growth hormone can be used to optimize long-term peripheral T-cell engraftment in these human-mouse chimeras and may also be useful clinically in treating T- cell deficiencies.
Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7.
TLDR
In the BMT-IL-7 mice, there was an eightfold increase in the number of immature CD3-CD4-CD8- thymocytes in G2-M of the cell cycle, indicating that restoration of thymic cellularity was due to enhanced proliferation of immatureThymic progenitors.
A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution.
TLDR
It is suggested that full-term fetal blood can engraft allogeneic hosts across the major histocompatibility barrier with slower hematopoietic engraftment and impaired immune reconstitution.
Effects of growth hormone on thymocyte development from progenitor cells in the bone marrow
Growth hormone exerts hematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine.
TLDR
GH exerts significant direct hematopoietic growth-promoting effects in vivo and may be of potential clinical use to promote hematocrit values and white blood cell counts in the face of myelotoxic therapy.
ENHANCEMENT OF THYMIC RECOVERY AFTER CYCLOSPORINE BY RECOMBINANT HUMAN GROWTH HORMONE AND INSULIN‐LIKE GROWTH FACTOR I
TLDR
It is concluded that rhGH and rhIGF-1 accelerate thymic regeneration post-CsA and further studies are now indicated to establish the potential for these factors to enhance the development of antigen-specific tolerance.
Pathways of T‐cell regeneration in mice and humans: implications for bone marrow transplantation and immmunotherapy
Summary: Much of our understanding of the immunobiology of bone marrow transplantation (BMT) has come from studies in young adult mice reconstituted with T‐cell‐depleted bone marrow after lethal
Common lymphoid progenitors rapidly engraft and protect against lethal murine cytomegalovirus infection after hematopoietic stem cell transplantation.
TLDR
It is demonstrated in mice that both congenic as well as allogeneic transplantation of low numbers of highly purified common lymphoid progenitors (CLPs) accelerated immune reconstitution after lethal irradiation and rescue with hematopoietic stem cells (HSCs) and provided a durable antiviral immunity without inducing GVHD.
Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation.
TLDR
Results demonstrate that KGF may have immunomodulatory effects by a unique mechanism of protection of TECs, and thymic injury and prolonged posttransplantation immune deficiency in BMT recipients can be prevented by KGF administration.
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