Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses.

@article{Roelfsema2001GrowthH,
  title={Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses.},
  author={Ferdinand Roelfsema and Nienke R Biermasz and R G Veldman and Johannes D. Veldhuis and Marikje Fr{\"o}lich and Wilhelmina H. Stokvis-Brantsma and Jan Maarten Wit},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 6},
  pages={
          2459-64
        }
}
GH secretion is regulated by the interaction of GHRH and somatostatin and is released in 10-20 pulses in each 24-h cycle. The exact roles in pulse generation played by somatostatin, GHRH, and the recently isolated GH-releasing peptide, Ghrelin, are not fully elucidated. To investigate the GHRH-mediated GH secretion in human, we investigated pulsatile, entropic, and 24-h rhythmic GH secretion in two young adults (male, 24 yr; female, 23 yr) from a Moroccan family with a novel inactivating defect… CONTINUE READING
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