Growth hormone (GH) insensitivity due to primary GH receptor deficiency.

  title={Growth hormone (GH) insensitivity due to primary GH receptor deficiency.},
  author={Ron G. Rosenfeld and Arlan L. Rosenbloom and Jaime Guevara-Aguirre},
  journal={Endocrine reviews},
  volume={15 3},
As demonstrated in Table 2, the differential diagnosis of growth hormone insensitivity (GHI) includes a number of discrete disorders that can be broadly classified as primary or secondary forms. We have selected GHRD (Laron syndrome) as the prototypic disorder of GHI, in part because such dramatic and rapid progress has been made in this clinical condition over the last 6 yr. These advances represent the fortunate convergence of: 1) the cloning of the GHR gene and the identification of… CONTINUE READING


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