Growth hormone: metabolic clearance rates, integrated concentrations, and production rates in normal adults and the effect of prednisone.

@article{Thompson1972GrowthHM,
  title={Growth hormone: metabolic clearance rates, integrated concentrations, and production rates in normal adults and the effect of prednisone.},
  author={Robert Thompson and Andrea V. Rodriguez and Avinoam A. Kowarski and Robert M Blizzard},
  journal={The Journal of clinical investigation},
  year={1972},
  volume={51 12},
  pages={3193-9}
}
A constant withdrawal pump was used to determine the integrated concentration of growth hormone (ICGH) which was used in conjunction with the metabolic clearance rate (MCR) of growth hormone (GH) to calculate the GH production rates (GHPR) in normal adults, acromegalics, and normal controls receiving prednisone. The mean ICGH for 22 premenopausal females on no medication was 3.0+/-1.6 ng/ml (sd) which is significantly lower (P < 0.005) than the mean of 6.6+/-2.9 for 10 women receiving oral… CONTINUE READING

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