Growth hormone, insulin-like growth factor I, and motoneuron size.

  title={Growth hormone, insulin-like growth factor I, and motoneuron size.},
  author={Liling Chen and Pauline Kay Lund and Steve Burgess and Bruce E. Rudisch and D L Mcilwain},
  journal={Journal of neurobiology},
  volume={32 2},
In this study we asked whether growth hormone (GH) and one of its key mediators, insulin-like growth factor I (IGF-I), influence spinal motoneuron size in conjunction with whole body size. We present evidence that GH has such a role, possibly without the mediation of IGF-I. Both lumbar motoneuron and body size were found to be increased relative to littermate controls in transgenic mice overexpressing GH, while body size, but not motoneuron size, was increased in mice overexpressing IGF-I. GH… CONTINUE READING

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