Growth hormone, arginine and exercise

  title={Growth hormone, arginine and exercise},
  author={Jill A Kanaley},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  • J. Kanaley
  • Published 1 January 2008
  • Medicine, Biology
  • Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of reviewTo describe the effect of an acute bout of exercise on growth hormone responses and to discuss the effect of L-arginine supplementation on growth hormone responses. Recent findingsRecent studies have shown that resting growth hormone responses increase with oral ingestion of L-arginine and the dose range is 5–9 g of arginine. Within this range there is a dose-dependent increase and higher doses are not well tolerated. Most studies using oral arginine have shown that arginine… 

Arginine and Ornithine Supplementation Increases Growth Hormone and Insulin-Like Growth Factor-1 Serum Levels After Heavy-Resistance Exercise in Strength-Trained Athletes

It appears that the GH/igF-1/IGFBP-3 complex may be the major player in muscle tissue response to short-term resistance training after arg and orn supplementation.

Oral L-arginine before resistance exercise blunts growth hormone in strength trained males.

L-arg inine ingested before resistance exercise significantly elevated plasma L-arginine concentration but attenuated plasma GH in strength trained individuals despite a lower GHIH, and the data shows that the GH suppression was not due to a GH or IGF-1 induced autonegative feedback loop.

The acute effects of L-arginine on hormonal and metabolic responses during submaximal exercise in trained cyclists.

The acute ingestion of L-arginine did not alter any hormonal, metabolic, or cardio-respiratory responses during submaximal exercise except for a small but significant increase in glycerol at the 45-min time point and a reduction in fat oxidation at the start of exercise.

Hemodynamic and vascular response to resistance exercise with L-arginine.

On the basis of data, l-arginine does not appear to change the hemodynamic and vascular responses to resistance exercise and blood flow was not augmented with supplementation.

l -Arginine, Pancreatic Beta Cell Function, and Diabetes: Mechanisms of Stimulated Insulin Release and Pathways of Metabolism

L-arginine has pronounced glucoregulatory and insulinotropic effects, stimulating insulin secretion acutely but reducing beta cell secretory function and proliferation following chronic exposure, and pigment epithelium-derived factor (PEDF) may be considered as a novel modulator of arginine metabolism and nitric oxide generation in the beta cell.

Growth Hormone and Insulin-like Growth Factor-I Molecular Weight Isoform Responses to Resistance Exercise Are Sex-Dependent

The data indicate that the processing of GH and IGF-I isoforms from the somatotrophs and hepatocytes are differential in their response to strenuous resistance exercise and reflect both temporal and sex-related differences.

Effects of Chronic Supplementation of L-Arginine on Physical Fitness in Water Polo Players

Chronic L-Arginine is safe and effective in ameliorating the oxidative metabolism of professional water polo players, through a mechanism of enhanced mitochondrial function.

Oral Supplementation with Beta-Hydroxy-Beta-Methylbutyrate, Arginine, and Glutamine Improves Lean Body Mass in Healthy Older Adults

Dietary supplementation with HMB, arginine, and glutamine improved total body lean mass among a small sample of healthy older adults and is indicated to elucidate mechanisms of action and whether supplementation may benefit frail elders.



Cortisol and Growth Hormone Responses to Exercise

The cortisol response pattern to exercise has been considered to be predictive of an individual’s adaptation to other forms of stress and the factors affecting this review discusses the cortisol and GH responses to exercise.

Oral arginine attenuates the growth hormone response to resistance exercise.

The combined effect of arginine before exercise attenuates the GH response, and autonegative feedback possibly causes a refractory period such that when the two stimuli are presented there will be suppression of the somatotrope.

Growth hormone responses to varying doses of oral arginine.

  • S. CollierDarren P. CaseyJ. Kanaley
  • Medicine
    Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2005

Effect of growth hormone and resistance exercise on muscle growth and strength in older men.

It is suggested that resistance exercise training improved muscle strength and anabolism in older men, but these improvements were not enhanced when exercise was combined with daily GH administration.

Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men.

It was concluded that ingestion of 1,500 mg arginine and 1, 500 mg lysine immediately before resistance exercise does not alter exercise-induced changes in [GH] in young men, however, when the same amino acid mixture is ingested under basal conditions, the acute secretion of GH is increased.

Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.

It is inferred that gender strongly controls the relative but not absolute magnitude of A/G synergy both at rest and after exercise, and exercise is likely to induce release of both GHRH and somatostatin.


Plasma levels of growth hormone have been shown to rise during or following spontaneous and experimentally induced hypoglycemia, prolonged fasting, vigorous muscular exercise, surgical stress, inhibition of glucose utilization by 2-desoxy-glucose, and a rapid and significant fall in blood glucose levels.

Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults.

Oral Arg does not stimulate GH secretion and may impair GH release during resistive exercise, and the efficacy of oral Arg to improve GH response to exercise has not been explored.

Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adults.

The results show that arginine potentiates the GHRH-induced GH secretion preventing the lessening of somatotrope responsiveness to the neurohormone alone, and gives further evidence of a somatostatin-suppressing effect of arkinine.