Growth hormone, arginine and exercise

@article{Kanaley2008GrowthHA,
  title={Growth hormone, arginine and exercise},
  author={J. Kanaley},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  year={2008},
  volume={11},
  pages={50–54}
}
  • J. Kanaley
  • Published 2008
  • Medicine
  • Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of reviewTo describe the effect of an acute bout of exercise on growth hormone responses and to discuss the effect of L-arginine supplementation on growth hormone responses. Recent findingsRecent studies have shown that resting growth hormone responses increase with oral ingestion of L-arginine and the dose range is 5–9 g of arginine. Within this range there is a dose-dependent increase and higher doses are not well tolerated. Most studies using oral arginine have shown that arginine… Expand

Topics from this paper

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TLDR
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TLDR
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TLDR
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References

SHOWING 1-10 OF 50 REFERENCES
Use of amino acids as growth hormone-releasing agents by athletes.
TLDR
No appropriately conducted scientific studies found that oral supplementation with amino acids, which are capable of inducing GH release, before strength training increases muscle mass and strength to a greater extent than strength training alone. Expand
Oral arginine attenuates the growth hormone response to resistance exercise.
TLDR
The combined effect of arginine before exercise attenuates the GH response, and autonegative feedback possibly causes a refractory period such that when the two stimuli are presented there will be suppression of the somatotrope. Expand
Growth hormone responses to varying doses of oral arginine.
  • S. Collier, Darren P. Casey, J. Kanaley
  • Biology, Medicine
  • Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
  • 2005
TLDR
A 13 g dose of arginine resulted in considerable gastrointestinal distress in most subjects without augmentation in the GH response and the rise in GH concentration started approximately 30 min after ingestion and peaked approximately 60 min post ingestion. Expand
Effect of growth hormone and resistance exercise on muscle growth and strength in older men.
TLDR
It is suggested that resistance exercise training improved muscle strength and anabolism in older men, but these improvements were not enhanced when exercise was combined with daily GH administration. Expand
Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men.
TLDR
It was concluded that ingestion of 1,500 mg arginine and 1, 500 mg lysine immediately before resistance exercise does not alter exercise-induced changes in [GH] in young men, however, when the same amino acid mixture is ingested under basal conditions, the acute secretion of GH is increased. Expand
Synergy of L-arginine and GHRP-2 stimulation of growth hormone in men and women: modulation by exercise.
  • L. Wideman, J. Weltman, +5 authors A. Weltman
  • Psychology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2000
TLDR
It is inferred that gender strongly controls the relative but not absolute magnitude of A/G synergy both at rest and after exercise, and exercise is likely to induce release of both GHRH and somatostatin. Expand
PLASMA GROWTH HORMONE RESPONSE TO INTRAVENOUS ADMINISTRATION OF AMINO ACIDS.
TLDR
Plasma levels of growth hormone have been shown to rise during or following spontaneous and experimentally induced hypoglycemia, prolonged fasting, vigorous muscular exercise, surgical stress, inhibition of glucose utilization by 2-desoxy-glucose, and a rapid and significant fall in blood glucose levels. Expand
Oral arginine does not stimulate basal or augment exercise-induced GH secretion in either young or old adults.
TLDR
Oral Arg does not stimulate GH secretion and may impair GH release during resistive exercise, and the efficacy of oral Arg to improve GH response to exercise has not been explored. Expand
Cortisol and growth hormone responses to exercise at different times of day.
TLDR
Time of day does not alter the GH response to exercise; however, the exercise-induced cortisol response is modulated by time of day. Expand
Arginine reinstates the somatotrope responsiveness to intermittent growth hormone-releasing hormone administration in normal adults.
TLDR
The results show that arginine potentiates the GHRH-induced GH secretion preventing the lessening of somatotrope responsiveness to the neurohormone alone, and gives further evidence of a somatostatin-suppressing effect of arkinine. Expand
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