Growth hormone, acromegaly, and heart failure: an intricate triangulation.

@article{Sacc2003GrowthHA,
  title={Growth hormone, acromegaly, and heart failure: an intricate triangulation.},
  author={Luigi Sacc{\'a} and Raffaele Napoli and Antonio Cittadini},
  journal={Clinical endocrinology},
  year={2003},
  volume={59 6},
  pages={660-71}
}
Short-term GH or IGF-I excess provides a model of physiological cardiac growth associated with functional advantage. The physiological nature of cardiac growth is accounted for by the following: (i) the increment in cardiomyocyte size occurs prevalently at expense of the short axis. This is the basis for the concentric pattern of left ventricular (LV) hypertrophy, with consequent fall in LV wall stress and functional improvement; (ii) cardiomyocyte growth is associated with improved… CONTINUE READING