Growth hormone, VEGF and FGF: involvement in rheumatoid arthritis.

  title={Growth hormone, VEGF and FGF: involvement in rheumatoid arthritis.},
  author={Charles J. Malemud},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={375 1-2},
Adult rheumatoid arthritis (RA), a systemic autoimmune disorder of unknown etiology, is characterized by dysfunctional cellular and humoral immunity, enhanced migration and attachment of peripheral macrophages and pro-inflammatory leukocytes to the synovium and articular cartilage of diarthrodial joints. The progressive destruction of cartilage and bone in RA is a result of elevated pro-inflammatory cytokine gene expression, synovial neovascularization, proteinase-mediated dissolution of… CONTINUE READING