Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.

@article{Mondschein1981GrowthFM,
  title={Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.},
  author={J S Mondschein and David W. Schomberg},
  journal={Science},
  year={1981},
  volume={211 4487},
  pages={1179-80}
}
Epidermal growth factor and fibroblast growth factor inhibited follicle-stimulating hormone-dependent induction of luteinizing hormone receptor in cultured ovarian granulosa cells of the rat. In contrast, platelet-derived growth factor potentiated the induction of luteinizing hormone receptor by follicle-stimulating hormone. These results indicate that growth factors, well known for their effects on mitosis and DNA synthesis in cultured mammalian cells, are also able to modulate hormone… CONTINUE READING

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