Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

@article{Lenormand1993GrowthFI,
  title={Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts},
  author={Pascal Lenormand and Claude Sardet and Gilles Pag{\'e}s and Gilles L'Allemain and Anne Sophie Brunet and Jacques M. Pouyssegur},
  journal={The Journal of Cell Biology},
  year={1993},
  volume={122},
  pages={1079 - 1088}
}
Mitogen-activated protein kinases (p42mapk and p44mapk) are serine/threonine kinases that are activated rapidly in cells stimulated with various extracellular signals. This activation is mediated via MAP kinase kinase (p45mapkk), a dual specificity kinase which phosphorylates two key regulatory threonine and tyrosine residues of MAP kinases. We reported previously that the persistent phase of MAP kinase activation is essential for mitogenically stimulated cells to pass the "restriction point… CONTINUE READING

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The mitogen activated protein kinases p 42 ~ * rk and p 44 ~ ' ~ are required for fibroblast cell proliferation

  • S. L. Pelech, J. S. Sanghera
  • 1993

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