Growth factors in induction of epithelial-mesenchymal transition and metastasis.

@article{Said2011GrowthFI,
  title={Growth factors in induction of epithelial-mesenchymal transition and metastasis.},
  author={Nur Akmarina B.M. Said and Elizabeth D. Williams},
  journal={Cells, tissues, organs},
  year={2011},
  volume={193 1-2},
  pages={85-97}
}
Epithelial to mesenchymal transition (EMT) has gained widespread acceptance over recent years as a mechanism by which normally sessile epithelial tumour cells can move away from the primary tumour and metastasize. This review article examines the role of a number of growth factors in inducing EMT, and the reverse process mesenchymal to epithelial transition. Unique and common intracellular signalling pathways are highlighted. A comprehensive understanding of the regulation of EMT will be… CONTINUE READING