Growth factors and extracellular signal-regulated kinases (mitogen-activated protein kinase) in the rat pineal gland.

Abstract

The present study revealed that the pineal gland expressed basic fibroblast growth factor (bFGF) and FGF-receptor 1 (FGFR1/flg), suggesting that bFGF in the pineal gland acts in an autocrine or paracrine manner, which is mediated by FGFR1/flg. The present study also examined gene expression of the extracellular signal-regulated kinase (ERK) family (ERK1-3) which may be intracellular signal mediators of growth factors. ERK1 [mitogen-activated protein kinase (MAP-kinase)] was strongly expressed throughout the pineal gland, while expression of ERK2 and ERK3 was not found. These findings suggest the presence of a signal pathway from bFGF to ERK1 via FGFR1/flg in the pineal gland.

Cite this paper

@article{Kiyama1994GrowthFA, title={Growth factors and extracellular signal-regulated kinases (mitogen-activated protein kinase) in the rat pineal gland.}, author={Hiroshi Kiyama and Akio Wanaka and Hiroshi Kato and H. Maeno and Koichi Matsumoto and Gang Sun and Sadao Shiosaka and Mikiko Tohyama}, journal={Neuroendocrinology}, year={1994}, volume={59 2}, pages={152-5} }