Growth factor requirements of childhood acute T-lymphoblastic leukemia: correlation between presence of chromosomal abnormalities and ability to grow permanently in vitro.

@article{Oconnor1991GrowthFR,
  title={Growth factor requirements of childhood acute T-lymphoblastic leukemia: correlation between presence of chromosomal abnormalities and ability to grow permanently in vitro.},
  author={Rosemary O'connor and Alessandra Cesano and Beverly J. Lange and Janet Finan and Peter C. Nowell and Steven C. Clark and Susana C. Raimondi and Giovanni Giacomo Rovera and Daniela Santoli},
  journal={Blood},
  year={1991},
  volume={77 7},
  pages={
          1534-45
        }
}
Cells from 10 cases of childhood acute T-lymphoblastic leukemia (T-ALL) were cultured in the presence of recombinant human interleukins (rhIL) or colony-stimulating factors (CSF) to analyze their growth factor requirements and differentiative potential. Although cells from most leukemic samples displayed a short-term proliferative response to several hematopoietic growth factors, only the ones featuring chromosomal translocations could be established as permanent cell lines. Two cell lines… CONTINUE READING

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