Growth factor requirements for DNA synthesis by Leydig cells from the immature rat.

@article{Khan1992GrowthFR,
  title={Growth factor requirements for DNA synthesis by Leydig cells from the immature rat.},
  author={Shafiq A Khan and Katja J Teerds and Jennifer H. Dorrington},
  journal={Biology of reproduction},
  year={1992},
  volume={46 3},
  pages={
          335-41
        }
}
Puberty in the male is dependent upon the elevated production of testosterone by the Leydig cells. LH affects this increase in testosterone output by increasing the total number of Leydig cells in the testis and by stimulating the steroidogenic pathway in these cells. Since Leydig cell proliferation is a prerequisite for the onset of puberty, we have examined the ability of LH and growth factors known to be present in the testis to promote DNA synthesis. Leydig cells were isolated from 21-day… CONTINUE READING
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