Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.

  title={Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line.},
  author={James Direnzo and Sabina Signoretti and Noriaki Nakamura and Ramon Rivera-Gonzalez and William Sellers and Massimo F. Loda and Myles Brown},
  journal={Cancer research},
  volume={62 1},
Carcinogenesis involves a multistep process whereby a normal healthy cell undergoes both immortalization and oncogenesis to become fully transformed. Immortalization results from the subversion of critical cell cycle regulatory checkpoints, thereby allowing a cell to extend its finite life span and to maintain telomeric length. Oncogenesis is the manifestation of additional genetic events that are capable of conferring upon the cell an actual growth advantage. Such an advantage may relieve a… CONTINUE READING

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