Growth factor regulation of chondrocyte integrins. Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen.

@article{Loeser1997GrowthFR,
  title={Growth factor regulation of chondrocyte integrins. Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen.},
  author={Richard F. Loeser},
  journal={Arthritis and rheumatism},
  year={1997},
  volume={40 2},
  pages={
          270-6
        }
}
OBJECTIVE The ability of growth factors to modulate integrin expression may be important with regard to processes involved in tissue repair and remodeling. This study was undertaken to determine the effect of transforming growth factor beta (TGF beta) and insulin-like growth factor 1 (IGF-1) on chondrocyte beta 1 integrin expression and integrin-mediated adhesion to extracellular matrix proteins. METHODS Chondrocytes obtained from normal bovine articular cartilage were cultured in the… CONTINUE READING
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