Growth factor regulation of chondrocyte integrins. Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen.


OBJECTIVE The ability of growth factors to modulate integrin expression may be important with regard to processes involved in tissue repair and remodeling. This study was undertaken to determine the effect of transforming growth factor beta (TGF beta) and insulin-like growth factor 1 (IGF-1) on chondrocyte beta 1 integrin expression and integrin-mediated… (More)


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