Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor


Neoplastic transformation is often related to abnormal activation of growth factor receptors and their signaling pathways. The concept of targeting specific tumorigenic receptors and/or signaling molecules has been validated by the development and successful clinical application of drugs acting against the epidermal growth factor receptor 2 (HER2/neu, Erb2… (More)
DOI: 10.1038/sj.onc.1206772


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