Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.

@article{Nadler2010GrowthFR,
  title={Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancer.},
  author={Yasmine Nadler and Ana Maria Gonzalez and Robert L. Camp and David L. Rimm and Harriet M. Kluger and Yuval Kluger},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2010},
  volume={21 3},
  pages={466-73}
}
BACKGROUND Growth factor receptor-bound protein-7 (Grb7) is an adapter-type signaling protein recruited to various tyrosine kinases, including HER2/neu. Grb7-specific inhibitors are in early development. As with other targeted therapies, response to therapy might be associated with target expression. MATERIALS AND METHODS Tissue microarrays containing 638 primary breast cancer specimens with 15-year patient follow-up were employed to assess Grb7 expression using our Automated QUantitative… CONTINUE READING

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