Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.

@article{Jang2011GrowthfactorRP,
  title={Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.},
  author={Ihn Kyung Jang and Darran G. Cronshaw and Luo-kun Xie and Guoqiang Fang and Jinping Zhang and Hyunju Oh and Yang-Xin Fu and Hua Gu and Yongrui Zou},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 19},
  pages={7926-31}
}
Grb2 (growth-factor receptor-bound protein-2) is a signaling adaptor that interacts with numerous receptors and intracellular signaling molecules. However, its role in B-cell development and function remains unknown. Here we show that ablation of Grb2 in B cells results in enhanced B-cell receptor signaling; however, mutant B cells do not form germinal centers in the spleen after antigen stimulation. Furthermore, mutant mice exhibit defects in splenic architecture resembling that observed in B… CONTINUE READING

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Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells

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