Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis

  title={Growth factor purification and delivery systems (PADS) for therapeutic angiogenesis},
  author={E. Marie George and Huiling Liu and Grant G Robinson and Fakhri Mahdi and Eddie Perkins and Gene L Bidwell},
  booktitle={Vascular cell},
BACKGROUND Therapeutic angiogenesis with vascular endothelial growth factor (VEGF), delivered either via recombinant protein infusion or via gene therapy, has shown promise in preclinical models of various diseases including myocardial infarction, renovascular disease, preeclampsia, and neurodegenerative disorders. However, dosing, duration of expression, and tissue specificity are challenges to VEGF gene therapy, and recombinant VEGF delivery suffers from extremely rapid plasma clearance… CONTINUE READING
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