Growth factor progranulin contributes to cervical cancer cell proliferation and transformation in vivo and in vitro.


OBJECTIVE The growth factor progranulin (PGRN) is overexpressed in a number of tumors. We aimed to investigate the expression and role of PGRN in cervical cancer tumorigenesis. METHODS PGRN expression and secretion was assessed in cells and normal and cancerous cervical tissues by Western blot analysis, ELISA or immunohistochemistry. The role of PGRN in… (More)
DOI: 10.1016/j.ygyno.2014.05.025


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