Growth factor pathways in development and progression of hepatocellular carcinoma.

  title={Growth factor pathways in development and progression of hepatocellular carcinoma.},
  author={Michael Andrew Nalesnik and George K Michalopoulos},
  journal={Frontiers in bioscience},
Hepatocellular carcinoma accounts for approximately 700,000 deaths per year. This tumor displays morphologic and phenotypic heterogeneity, and heterogeneity extends to the molecular level. Nevertheless, common pathways have been identified that are variably employed by these tumors. Such pathways often include aberrant signaling by growth factors, many of which are involved in liver development and regeneration. This review focuses on several such pathways and highlights patterns of structural… CONTINUE READING
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