Growth factor osteogenic protein-1: differing effects on cells from three distinct zones in the bovine intervertebral disc.

@article{Zhang2004GrowthFO,
  title={Growth factor osteogenic protein-1: differing effects on cells from three distinct zones in the bovine intervertebral disc.},
  author={Yejia Zhang and Howard S. An and Shiwen Song and Marc Toofanfard and Koichi Masuda and Gunnar B. J. Andersson and Eugene J-M A Thonar},
  journal={American journal of physical medicine & rehabilitation},
  year={2004},
  volume={83 7},
  pages={515-21}
}
OBJECTIVE The objective of this study was to determine if cells isolated from three distinct zones in the bovine intervertebral disc (IVD) differ in their response to growth factor osteogenic protein-1 (OP-1) because of inherent biological differences. The new knowledge gained will help determine if treatment of degenerative disc disease with purified growth factors is effective and will provide guidance in terms of the injection technique and frequency of treatments required. DESIGN This was… CONTINUE READING

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