Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease.

@article{Barone2007GrowthFA,
  title={Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease.},
  author={Maria Vittoria Barone and Anna Gimigliano and Gabriella Castoria and Giovanni Paolella and Francesco Maurano and Franco Paparo and Maria Antonia Maglio and Alba Mineo and Erasmo Miele and Merlin Nanayakkara and Riccardo Troncone and Salvatore Auricchio},
  journal={Gut},
  year={2007},
  volume={56 4},
  pages={
          480-8
        }
}
BACKGROUND Gliadins, a family of wheat proteins, are central to the pathogenesis of celiac disease (CD). In addition to 'immunogenic' effects, gliadin directly affects cultured cells and intestine preparations, and produces damage in vivo, via a separate 'toxic' peptide, such as A-gliadin p31-43 (P31-43). AIMS Understanding the molecular mechanisms underlying direct non T-cell mediated effects of gliadin peptides, and assessing their potential role in promoting CD. METHOD Gliadin effects… CONTINUE READING
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